The PROTEOSTEM lab is led by Dr. William Grey at the University of York.
We focus on the role of protein homeostasis – so called “Proteostasis” – in healthy and malignant stem cell development.
The predominant focus of the lab is the haematopoietic (blood) system and cancerous transformation to acute myeloid leukaemia (AML).
RECENT PUBLICATIONS
Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones
Bahou et al. (2023) Biomacromolecules
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
Tsutsumi et al. (2023) Cell
The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function
Grey et al. (2023) Hemasphere
NEWS
4 Fully Funded PhDs advertised now
Interested in doing a PhD with the ProteoStem group? We have 4 fully funded PhD positions available starting in 2024. See here for details: https://x.com/Bill_G_Grey/status/1717908866686484715?s=20
Welcome Max
Welcome to Max Ter-Grigoryan who is joining us for their intercalating Master’s project. Max will be studying trafficking of proteins between the cytoplasm and nucleus in haematopoeitic stem cells. Max is on the lookout for PhDs, so get reach out at: [email protected] if you want a motivated student starting in 2024
Welcome Megan!
Welcome to Megan our new MRC DiMeN DTP PhD student. Megan joins us after completing her MRes in Liverpool and will be focusing on proteostasis in haematopoietic stem cells. Check out Megan’s bio on our Teams page.
Welcome Katie!
Today we welcome Katie Trueman to the Grey lab. Katie is joining us for a year to work on projects involving spectral unmixing flow cytometry and high parameter imaging. Check out Katie’s bio on our Teams page.
New publication!
We are proud to report that our latest work has been published in Cell. This work is a close collaboration with the Hitchcock lab at the University of York and collaborators at Stanford University (U.S.A.). Check our our new article: https://doi.org/10.1016/j.cell.2023.07.037